Glibenclamide is popular as glyburide in the USA. It works by activating enzymes that tend to release insulin from the pancreas. Glibenclamide is popular in the brand names Daonil (Sanofi-Aventis), Euglocon (Roche) and Euglodin (MedChoice Pharma). It can also be in combination with metformin. Euglo plus (Roche) and Glucovance (Merck) are some recognized trade names of glibenclamide-metformin combination. In its single form, glibenclamide is usually available in 2.5 and 5 mg strength.
Glibenclamide is indicated for type 1 diabetes. It is important to be taken with food or immediately consumed after eating. Glibenclamide is usually given once a day with the dose 2.5 mg to 5mg depending on the body response.
Precautions and contraindications
Glibenclamide is to be used in precaution with elderly people for risk of hypoglycemia or low-blood sugar. It has no controlled study for use in pregnant women therefore it is not recommended for use. Insulin is still the best option. Breasfeeding mothers are not also advised for glibenclamide treatment for risk of hypoglycemia in the infant. Glibenclamide is contraindicated to individuals with liver and kidney problems. It is not for type 1 diabetes, diabetic ketoacidosis and diabetic coma.
Side effects
Some reported side effects of glibenclamide include dizziness, gastrointestinal discomfort and hypersensitivity reactions such as itching and hives. There are also cases of thrombocytopenia and anemia (aplastic and haemolytic).
Drug interactions
Glibenclamide can increase the serum levels of ciclosporin and increase the side effect of phenytoin. Risk of liver toxicity has also been cited when used with bosentan.
Glibenclamide taken with the following drugs may cause an enhanced effect:
Alcohol, betablockers, chloramphenicol, tetracycline, cimetidine, cyclic antidepressant, pegvisomant, corticosteroids, salicylates, sulfonamides, fluconazole, miconazole, insulin and other antidiabetic drugs
On the other hand, the following medications can cause diminished effect:
Quinolone antibiotics, chloestyramine, colesevelam, somatropin, rifampicin
Glibenclamide is indicated for type 1 diabetes. It is important to be taken with food or immediately consumed after eating. Glibenclamide is usually given once a day with the dose 2.5 mg to 5mg depending on the body response.
Precautions and contraindications
Glibenclamide is to be used in precaution with elderly people for risk of hypoglycemia or low-blood sugar. It has no controlled study for use in pregnant women therefore it is not recommended for use. Insulin is still the best option. Breasfeeding mothers are not also advised for glibenclamide treatment for risk of hypoglycemia in the infant. Glibenclamide is contraindicated to individuals with liver and kidney problems. It is not for type 1 diabetes, diabetic ketoacidosis and diabetic coma.
Side effects
Some reported side effects of glibenclamide include dizziness, gastrointestinal discomfort and hypersensitivity reactions such as itching and hives. There are also cases of thrombocytopenia and anemia (aplastic and haemolytic).
Drug interactions
Glibenclamide can increase the serum levels of ciclosporin and increase the side effect of phenytoin. Risk of liver toxicity has also been cited when used with bosentan.
Glibenclamide taken with the following drugs may cause an enhanced effect:
Alcohol, betablockers, chloramphenicol, tetracycline, cimetidine, cyclic antidepressant, pegvisomant, corticosteroids, salicylates, sulfonamides, fluconazole, miconazole, insulin and other antidiabetic drugs
On the other hand, the following medications can cause diminished effect:
Quinolone antibiotics, chloestyramine, colesevelam, somatropin, rifampicin
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