Antidepressant medications work by either sedating or stimulating the patient. Tofranil (Imipramine) for instance, is a tricyclic antidepressant, under the dimethlyamino acid compounds. This drug promotes restfulness. Ludiomil (Maprotiline) on the other hand, acts as a stimulant. The latter is also under the tricyclic antidepressant, but categorized as a monomethyl relative.
To prevent any interactions, antidepressant drugs should not be taken with other medicine that act on the central nervous system. This safety measure should also be applied with supplements. The following are herbal supplements that should be avoided if you are taking antidepressant medications.